The Team

Shakir Chowdhury


PhD Candidate and Clinical Researcher


After my MPhil in Ageing and Obesity, I became actively involved in developing strategies to improve lifestyle in my local community. Driven by the increasing amount of cardiovascular disease cases I saw, and the positive impact physical activity had on health outcomes, I decided to research further on the mechanisms involved in the pathogenesis of metabolic disease, CVD, oxidative stress and how lifestyle modifications could improve health outcomes in these patients. There is strong evidence that diabetes/hyperglycaemia can result in a state of oxidative stress and that reactive oxygen species contribute to the production of insulin resistance, β-cell dysfunction and both contributing to micro and macrovascular long-term complications of diabetes. The prevalence of diabetes for all age-groups worldwide was estimated to be 2.8% in 2000 and 4.4% in 2030. The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030.

My PhD looks at how combining physical activity, diet and enhanced serviced pathway can affect diabetic patients. More specifically, I am studying the mechanisms involved in improvements in metabolic function, cardiac function and oxidative stress functions resulting from this intervention and how subsequent relapse can become detrimental to health. An increasing body of evidence suggests that oxidant stress is involved in the pathogenesis of many cardiovascular diseases, including hypercholesterolemia, atherosclerosis, hypertension, heart failure and diabetes. My role in this department is to assess and review the effects of diabetes on endothelial and metabolic function as well as the interaction of reactive oxygen species in diabetics and address possible therapeutic interventions.


Phone: 0191 208 8264

Email: shakir [DOT] chowdhury [AT] newcastle [DOT] ac [DOT] uk