Research

Metabolic Disease

Autonomic function in liver disease

Project:

Autonomic function in liver disease

Team:

    Aim:

    1. This study aims to characterise autonomic function and cardiac output in non-alcoholic fatty liver disease (NAFLD) patients to stratify those who are at greater risk of developing cardiovascular disease.

    Research Overview:

    The autonomic nervous system (ANS) is a division of the nervous system that influences the function of internal organs including the cardiovascular system. Autonomic dysfunction is an umbrella term that is used when the ANS is not working properly, which can lead to health problems. Autonomic dysfunction is common in liver disease across all aetiologies and is more severe in those awaiting liver transplants. Patients with liver disease are at greater risk of cardiovascular disease, which paired with autonomic dysfunction places greater risk on the cardiovascular system and increases the risk of serious cardiovascular health complications.

    Research Importance:

    This study will aim to characterise autonomic dysfunction in relation to cardiac output in patients with NAFLD and potentially address those at greater risk of developing cardiovascular disease. This has the potential to improve risk stratification and clinical outcomes in patients with NAFLD.